关景洋 博士 助理教授（研究员，博士生导师）

北京大学医学部药学院

地址：北京市海淀区学院路38号医学科学楼   邮编：100191

Email：guanjingyang@hsc.pku.edu.cn

教育及工作经历:

2006-2010：北京科技大学，生物技术系，理学学士

2010-2015：北京大学，生命科学学院，细胞生物学理学博士

2015-2023：北京大学，北大-清华生命联合中心; 生命科学学院，博士后

2023-至今： 北京大学药学院/北京大学干细胞与再生医学中心

以药物开发和应用为目标，研究兴趣集中:

1. 开发制备干细胞，功能细胞等新方法策略，用于细胞治疗，药物筛选及疾病模型构等

2. 解析细胞命运重编程调控细胞性质转变的基本规律，发现调控细胞命运的新靶点和机理

3. 借助体内外模型，基于细胞命运调控理论，开发难再生组织器官的修复和再生新策略
 

1. Yanglu Wang#, Fangqi Peng#, Zhihan Yang#, Lin Cheng#, Jingxiao Cao#, Xiaodi Fu, Huanjing He, Ruyi Cai, Weizhen Zeng, Yingshuai Dong, Guanxian Chen, Gongxin Peng, Shijia Liuyang, Guan Wang, Jinlin Wang, Rong Mu, Cheng Li, Jingyang Guan*, Hongkui Deng*, A Rapid Chemical Reprogramming System to Generate Human Pluripotent Stem Cells, Nature Chemical Biology, 2025 Jan 3. (*Corresponding Author)

2. Jialiang Zhu#, Xinxing Zhong#, Huanjing He#, Jingxiao Cao#, Zhengyang Zhou, Jiebin Dong, Honggang Li, Anqi Zhang, Yulin Lyu, Cheng Li, Jingyang Guan*, Hongkui Deng*, Generation of human expandable limb-bud progenitors via chemically induced dedifferentiation, Cell Stem Cell, 2024, Oct 16: S1934-5909(24)00363-1 (*Corresponding Author)

3. Guan Wang#, Yanglu Wang#, Yulin Lyu#, Huanjing He#, Shijia Liuyang#, Jinlin Wang#, Shicheng Sun#, Lin Cheng, Yao Fu, Jialiang Zhu, Xinxing Zhong, Zhihan Yang, Jingyang Guan*, Hongkui Deng*, Chemical-induced epigenome resetting for regeneration program activation in human cells, Cell Reports, 2023, May 23;42(6):112547. (*Corresponding Author)

4. Shijia Liuyang#, Guan Wang#, Yanglu Wang#, Huanjing He#, Yulin Lyu#, Lin Cheng, Zhihan Yang, Jingyang Guan, Yao Fu, Jialiang Zhu, Xinxing Zhong, Shicheng Sun, Cheng Li, Jinlin Wang*, Hongkui Deng*, Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming, Cell Stem Cell, 2023, Apr 6;30(4):450-459.e9.

5. Jingyang Guan#, Guan Wang#, Jinlin Wang#*, Zhengyuan Zhang#, Yao Fu#, Lin Cheng#, Gaofan Meng#, Yulin Lyu#, Jialiang Zhu, Yanqin Li, Yanglu Wang, Shijia Liuyang, Bei Liu, Zirun Yang, Huanjing He, Xinxing Zhong, Qijing Chen, Xu Zhang, Shicheng Sun, Weifeng Lai, Yan Shi, Lulu Liu, Lipeng Wang, Cheng Li, Shichun Lu*, Hongkui Deng*, Chemical reprogramming of human somatic cells to pluripotent stem cells, Nature, 2022, 605(7909):325-331.

6. Yuanyuan Du#, Zhen Liang#, Shusen Wang#, Dong Sun#, Xiaofeng Wang#, Soon Yi Liew#, Shuaiyao Lu#, Shuangshuang Wu, Yong Jiang, Yaqi Wang, Boya Zhang, Wenhai Yu, Zhi Lu, Yue Pu, Yun Zhang, Haiting Long, Shanshan Xiao, Rui Liang, Zhengyuan Zhang, Jingyang Guan, Jinlin Wang, Huixia Ren, Yanling Wei, Jiaxu Zhao, Shicheng Sun, Tengli Liu, Gaofan Meng, Le Wang, Jiabin Gu, Tao Wang, Yinan Liu, Cheng Li, Chao Tang, Zhongyang Shen*, Xiaozhong Peng*, Hongkui Deng*, Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates. Nature Medicine 2022, 28, 272–282.

7. Molong Qu#, Liang Xiong#, Yulin Lyu#, Xiannian Zhang, Jie Shen, Jingyang Guan, Peiyuan Chai, Zhongqing Lin, Boyao Nie, Cheng Li*, Jun Xu*, Hongkui Deng*. Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration, Cell Research, 2021, 31: 259–271.

8. Xiang Li#, Defang Liu#, Yantao Ma#, Xiaomin Du#, Junzhan Jing#, Lipeng Wang, Bingqing Xie, Da Sun, Shaoqiang Sun, Xueqin Jin, Xu Zhang, Ting Zhao, Jingyang Guan, Zexuan Yi, Weifeng Lai, Ping Zheng, Zhuo Huang, Yanzhong Chang, Zhen Chai*, Jun Xu, Hongkui Deng*, Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State, Cell Stem Cell, 2017, 21(2):264-273.

9. Yang Zhao#*, Ting Zhao#, Jingyang Guan#, Xu Zhang#, Yao Fu#, Junqing Ye, Jialiang Zhu, Gaofan Meng, Jian Ge, Susu Yang, Lin Cheng, Yaqin Du, Chaoran Zhao, Ting Wang, Linlin Su, Weifeng Yang, Hongkui Deng*, A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming, Cell, 2015,163(7):1678-91.（#Co-First Author）

10. Pingping Hou#, Yanqin Li#, Xu Zhang#, Chun Liu#, Jingyang Guan#, Honggang Li#, Ting Zhao, Junqing Ye, Weifeng Yang, Kang Liu, Jian Ge, Jun Xu, Qiang Zhang, Yang Zhao*, Hongkui Deng*, Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds, Science, 2013,341(6146):651-4.（#Co-First Author）

参与组织或讲授的本科生及研究生课程：

1. 本科生必修课《细胞与分子生物学II》

2. 本科生必修课《药理学》

3. 本科生必修课《人体解剖生理学》

4. 研究生选修课《前沿生物技术专论》

本实验室长期招收干细胞与再生医学、细胞生物学及生物信息学方向的博士后、研究生及科研助理，欢迎感兴趣的老师同学随时邮件联系！