关景洋 博士 副研究员
地址：北京大学海淀区学院路38号医学科学楼 邮编：100191
Email：guanjingyang@hsc.pku.edu.cn
教育工作经历:
2006/9-2010/7：北京科技大学，生物技术系，理学学士
2010/9-2015/7：北京大学，生命科学学院，细胞生物学，理学博士
2015/10-2023/1：北京大学，生命科学学院，北大-清华生命联合中心，博士后研究
2023/3-至今：北京大学医学部，药学院
课题组研究兴趣主要集中再生医学领域，尤其是干细胞及细胞命运调控方向。以第一或共同第一作者身份的在Science，Cell，Nature等杂志发表科研论文，建立了化学重编程诱导人多能干细胞技术，为人多能干细胞的制备提供了全新的途径。相关研究成果被评为中国科学十大进展（2013）、中国生命科学领域十大进展（2015）和中国基础医学与生物学重要进展（2023）。
以药物开发和应用为目标和导向，研究兴趣集中：
1. 开发和发展新的方法制备干细胞，功能细胞及三维类器官等，用于药物筛选，疾病模型构建及细胞治疗等；
2. 研究细胞命运重编程中，调控细胞命运转变的基本生物学规律，发现调控细胞命运的新靶点和机理；
3. 借助体内外疾病模型，基于细胞命运调控理论，筛选针对特定疾病的新靶点及调控分子。
发表论文:
1. Guan Wang#, Yanglu Wang#, Yulin Lyu#, Huanjing He#, Shijia Liuyang#, Jinlin Wang#, Shicheng Sun#, Lin Cheng, Yao Fu, Jialiang Zhu, Xinxing Zhong, Zhihan Yang, Jingyang Guan*, Hongkui Deng*, Chemical-induced epigenome resetting for regeneration program activation in human cells, Cell Reports, 2023,May 23;42(6):112547. (*Corresponding Author)
2. Shijia Liuyang#,Guan Wang#, Yanglu Wang#, Huanjing He#, Yulin Lyu#, Lin Cheng, Zhihan Yang, Jingyang Guan, Yao Fu, Jialiang Zhu, Xinxing Zhong, Shicheng Sun, Cheng Li, Jinlin Wang*, Hongkui Deng*, Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming, Cell Stem Cell, 2023, Apr 6;30(4):450-459.e9.
3. Jingyang Guan#, Guan Wang#, Jinlin Wang#*, Zhengyuan Zhang#, Yao Fu#, Lin Cheng#, Gaofan Meng#, Yulin Lyu#, Jialiang Zhu, Yanqin Li, Yanglu Wang, Shijia Liuyang, Bei Liu, Zirun Yang, Huanjing He, Xinxing Zhong, Qijing Chen, Xu Zhang, Shicheng Sun, Weifeng Lai, Yan Shi, Lulu Liu, Lipeng Wang, Cheng Li, Shichun Lu*, Hongkui Deng*, Chemical reprogramming of human somatic cells to pluripotent stem cells, Nature, 2022, 605(7909):325-331.
4. Yuanyuan Du#, Zhen Liang#, Shusen Wang#, Dong Sun#, Xiaofeng Wang#, Soon Yi Liew#, Shuaiyao Lu#, Shuangshuang Wu, Yong Jiang, Yaqi Wang, Boya Zhang, Wenhai Yu, Zhi Lu, Yue Pu, Yun Zhang, Haiting Long, Shanshan Xiao, Rui Liang, Zhengyuan Zhang, Jingyang Guan, Jinlin Wang, Huixia Ren, Yanling Wei, Jiaxu Zhao, Shicheng Sun, Tengli Liu, Gaofan Meng, Le Wang, Jiabin Gu, Tao Wang, Yinan Liu, Cheng Li, Chao Tang, Zhongyang Shen*, Xiaozhong Peng*, Hongkui Deng*,Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates. Nature Medicine 2022, 28, 272–282.
5. Molong Qu#, Liang Xiong#, Yulin Lyu#, Xiannian Zhang, Jie Shen, Jingyang Guan, Peiyuan Chai, Zhongqing Lin, Boyao Nie, Cheng Li*, Jun Xu*, Hongkui Deng*. Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration, Cell Research, 2021, 31:259–271.
6. Xiang Li#, Defang Liu#, Yantao Ma#, Xiaomin Du#, Junzhan Jing#, Lipeng Wang, Bingqing Xie, Da Sun, Shaoqiang Sun, Xueqin Jin, Xu Zhang, Ting Zhao, Jingyang Guan, Zexuan Yi, Weifeng Lai, Ping Zheng, Zhuo Huang, Yanzhong Chang, Zhen Chai*, Jun Xu, Hongkui Deng*, Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State, Cell Stem Cell, 2017, 21(2):264-273.
7. Yang Zhao#*, Ting Zhao#, Jingyang Guan#, Xu Zhang#, Yao Fu#, Junqing Ye, Jialiang Zhu, Gaofan Meng, Jian Ge, Susu Yang, Lin Cheng, Yaqin Du, Chaoran Zhao, Ting Wang, Linlin Su, Weifeng Yang, Hongkui Deng*, A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming,Cell, 2015,163(7):1678-91.（#Co-First Author）
8. Pingping Hou#, Yanqin Li#, Xu Zhang#, Chun Liu#, Jingyang Guan#, Honggang Li#, Ting Zhao, Junqing Ye, Weifeng Yang, Kang Liu, Jian Ge, Jun Xu, Qiang Zhang, Yang Zhao*, Hongkui Deng*, Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds, Science,2013,341(6146):651-4.（#Co-First Author）
