刘涛，北京大学药学院教授，博导，国家杰出青年基金获得者
担任分子与细胞药理学系主任，天然药物及仿生药物全国重点实验室PI，化学生物学交叉中心PI。担任Journal of Molecular Biology编委，Chinese Chemical Letter编委。任中国医药生物技术协会合成生物学分会委员，中国生物医学工程学会青工委委员，获国家杰青，国家优青，国家高层次青年人才，北京市杰青，中国药学会生物医药青年奖，拜耳学者奖，屠呦呦青年学者奖，北大王选青年学者奖等。以通讯作者身份在Nat Chem Biol、Mol Cell、Nat. Commun、Sci Adv、Chem、JACS、Angew Chem等发表论文30余篇。研究集中在发展可遗传编码的蛋白质精准化学修饰技术，并将化学修饰策略应用于蛋白质药物，基因治疗及细胞治疗等领域，从而促进了生物技术药物的升级换代与创新。
研究方向：1. 蛋白质化学生物学，2. 细胞合成生物学，3. 生物技术制药
电话：010-82805519
电子邮箱：taoliu@bjmu.edu.cn
代表性论文：
1. Chao Chen, Guiling Yu, Yujia Huang, Wenhui Cheng, Yuxuan Li, Yi Sun, Haifeng Ye*, and Tao Liu*. “Genetic code expanded cell-based therapy for treating diabetes in mice”. Nature Chemical Biology 2022 18, 47–55
2. Yong Wang, Jingming Zhang, Boyang Han, Linzhi Tan, Wenkang Cai, Yuxuan Li, Yeyu Su, Yutong Yu, Xin Wang, Xiaojiang Duan, Haoyu Wang, Xiaomeng Shi, Jing Wang, Xing Yang*, Tao Liu* “Noncanonical amino acids as doubly bio-orthogonal handles for one-pot preparation of protein multiconjugates” Nature Communications, 2023, 14, 974
3. Wenbing Cao, Haoyu Wang, Mao Quan, Yuxuan Li, Yeyu Su, Yuhang Li, Wei Jiang, Tao Liu* “Reversible control of tetrazine bioorthogonal reactivity by naphthotube-mediated host-guest recognition” Chem 2023;9,10, 2881-2901
4. Xinyu Ling, Liying Chang, Heqi Chen, Xiaoqin Gao, Jianhang Yin, Yi Zuo, Yujia Huang, Bo Zhang, Jiazhi Hu and Tao Liu*. “Improving the efficiency of CRISPR-Cas12a based genome editing with site-specific covalent Cas12a-crRNA conjugates”. Molecular Cell 2021 81(22), 4747-4756.
5. Xinyu Ling, Bingteng Xie, Xiaoqin Gao, Liying Chang, Wei Zheng, Heqi Chen, Yujia Huang, Linzhi Tan, Mo Li* and Tao Liu*. “Improving the Efficiency of Precise Genome Editing with Site-Specific Cas9-Oligonucleotide Conjugates”. Science Advances 2020, 8;6(15):eaaz0051.
6. Yong Wang, Xiaoxu Chen, Wenkang Cai, Linzhi Tan, Yutong Yu, Boyang Han, Yuxuan Li, Yuanzhe Xie, Yeyu Su, Xiaozhou Luo and Tao Liu*. “Expanding the structure diversity of protein building blocks with biosynthesized noncanonical amino acids from aromatic thiols”. Angew. Chem. Int. Ed. 2021, 60(18):10040-10048.
7. Hongting Tang, Zhen Dai, Xuewen Qin, Wenkang Cai, Liming Hu, Yujia Huang, Wenbing Cao, Fan Yang, Chu Wang, and Tao Liu*. “Proteomic Identification of Protein Tyrosine Phosphatase and Substrate Interactions in Living Mammalian Cells by Genetic Encoding of Irreversible Enzyme Inhibitors.” J Am Chem Soc. 2018 140(41):13253-13259.
