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朱元军

  

  朱元军,男,博士,北京大学药学院讲师。在Biochemical Pharmacology、Scientific reports等杂志上发表多篇论文,以及发明专利3项。主持国家自然科学基金(青年基金)1项和北京市自然基金(青年基金)1项,参与多个项目研究。

  研究方向:蛋白质/多肽设计;心血管药理。  电话:(010)-8280 1703(办公室)

  E-mail:zhuyuanjun@bjmu.edu.cn

  教育经历

  2007-2010年,北京协和医学院, 博士。

  1999-2007年,四川大学华西医学中心,本科,硕士。

  发表文章

  1. 1. Yuanjun Zhu, Yuan Lin, Aihua Liu, Mengyang Shui, Ruyi Li, Xiaoyan Liu, Wenhui Hu, Yinye Wang. Structure-guided creation of AcAP5-derived and platelet targeted factor Xa inhibitors. Biochemical Pharmacology. 2015, 95(4):253-62.
  2. 2. Yuanjun Zhu#, Yuanqing Gao#, Danping Zheng#, Mengyang Shui, Kuai Yu, Xiaoyan liu, Yuan Lin, Li Su, Wenxing Yang, Yinye Wang*. Design and evaluation of EphrinA1 mutants with cerebral protective effect. Scientific Reports, 2017; 7: 1881.
  3. 3. Yuanjun Zhu#, Ruyi Li#, Yuan Lin, Mengyang Shui, Xiaoyan Liu, Huan Chen, Yinye Wang*. Engineering Factor Xa Inhibitor with Multiple Platelet-Binding Sites Facilitates its Platelet Targeting. Scientific Reports. 2016, 6: 29895.
  4. 4. Yuanjun Zhu#, Mengyang Shui#, Xiaoyan Liu, Wenhui Hu*, Yinye Wang*.Increased autophagic degradation contributes to the neuroprotection of hydrogen sulfide against cerebral ischemia/reperfusion injury. Metabolic Brain Disease, 2017, doi: 10.1007/s11011-017-0014-4.
  5. 5. Yuanjun Zhu#, Tongliang Zhou#, Lingfei Yang, Lan Yuan, Lei Liang*, Ping Xu*.Revelation of the dynamic progression of hypoxia-reoxygenation injury by visualization of the lysosomal hydrogen peroxide. Biochemical & Biophysical Research Communication, 2017, 486 (4):904-908.
  6. 6. Tongliang Zhou, Lingfei Yang, Lei Liang*, Hui Liu, Yuanjun Zhu*, Mengyang Shui, Lan Yuan*, Fengrong Xu, Yan Niu, Chao Wang, and Ping Xu*. Rational Design of a Near-infrared Fluorescent Probe Based on Pyridazinone Scaffold. European Journal of Organic Chemistry. 2017, 3274–3281.
  7. 7. Lingfei Yang#, Yuanjun Zhu#, Mengyang Shui, Tongliang Zhou, Yuanbo Cai, Wei Wang, Fengrong Xu, Yan Niu, Chao Wang, Ping Xu*, Lan Yuan*, Lei Liang*. Rational Design of Fluorescent Phthalazinone Derivatives for One- and Two-Photon Imaging. Chemistry - A European Journal. 2016, 22(35):12363-70.
  8. 8. Yuanjun Zhu#, Qixin Bu#, Xiaoyan Liu, Wenhui Hu, Yinye Wang*. Neuroprotective Effect of TAT-14-3-3 epsilon Fusion Protein against Cerebral Ischemia/Reperfusion Injury in Rats. PLoS One. 2014, 9(3): e93334.
  9. 9. Yuanjun Zhu#, Yuan Lin#, Xiaoyan Liu, Wenhui Hu*, Yinye Wang*. Identification of AcAP5 as a novel factor Xa inhibitor with both direct and allosteric inhibition. Biochemical and Biophysical Research Communications, 2017, 483(1):495-501.
  10. 10. Yuanjun Zhu#, Aihua Liu#, Xiaoyan Liu, Yinye Wang*. Engineering Novel Anticoagulant Proteins by Motif Grafting. Protein and Peptide Letters. 2014, 21(2):159-63.
  11. 11. Mengyang Shui, Xiaoyan Liu, Yuanjun Zhu*, Yinye Wang*. Exogenous hydrogen sulfide attenuates cerebral ischemia-reperfusion injury by inhibiting  autophagy in mice. Canadian Journal of Physiology and Pharmacology, 2016, 94(11): 1187-1192.

  专利

  1. 1. 王银叶、高远晴、朱元军、刘晓岩、张烨. 重组生促红素肝细胞受体A2拮抗剂及其编码基因和应用201510191121.3
  2. 2. 王银叶,丁双,刘晓岩,朱元军。犬钩虫抗凝肽及其突变体在制备溶血栓药物中的应用途。2011.04,中国,201110106956.6。