朱元军，博士，北京大学药学院副研究员。主要研究方向为蛋白质/多肽药物的设计与递送、基于内源性蛋白质的药物递送。主持国家自然科学基金面上项目、北京市自然基金面上项目等多项基金，在ACS NANO、Molecular Therapy、J Control Release等国际知名期刊发表多篇SCI论文，获授权发明专利3项，担任人民卫生出版社《生物技术药物学》第9版教材编委。

E-mail: zhuyuanjun@bjmu.edu.cn

发表文章：

1. 1. Shi-He Cui^#, Yi Yan^#, An Lu^#, Yun Dou, Zhen-Wen Li, Ze-Hang Zhu, Ming-Ze Du, Yue-Feng Zhu, Xin Chen, Xiangyu Wang, Lin-Xia Jiang, Yujie Shi, Xiaoyan Liu, Yuan-Jun Zhu^*, Dong Jiang^*, Jian-Cheng Wang^*。Nanomedicines Promote Cartilage Regeneration in Osteoarthritis by Synergistically Enhancing Chondrogenesis of Mesenchymal Stem Cells and Regulating Inflammatory Environment. ACS Nano 2024,18(11):8125-8142.
2. 2. Yuanjun Zhu^#, A Sami Saribas^#, Jinbiao Liu, Yuan Lin, Brittany Bodnar, Ruotong Zhao, Qian Guo, Julia Ting, Zhengyu Wei, Aidan Ellis, Fang Li, Xu Wang, Xiaofeng Yang, Hong Wang, Wen-Zhe Ho, Ling Yang, Wenhui Hu^*. Protein expression/secretion boost by a novel unique 21-mer cis-regulatory motif (Exin21) via mRNA stabilization. Molecular Therapy. 2023, 31(4):1136-1158.
3. 3. Yuanjun Zhu#, Hu-Hu Han#, Lin Zhai#, Yi Yan, Xiaoyan Liu, Yinye Wang, Liandi Lei, Jian-Cheng Wang*. Engineering a "three-in-one" hirudin prodrug to reduce bleeding risk: A proof-of-concept study. J Control Release. 2021, 338:462-471.
4. 4. Junda Wang#, Yuanjun Zhu^#, Lingfei Yang, Hui Liu, Tongliang Zhou, Fengrong Xu, Ping Xu*, Lan YuanLan Yuan, Lei Liang*. Early Diagnosis of Cerebral Ischemia Reperfusion Injury and Revelation of Its Regional Development by a H3R Receptor-Directed Probe. ACS Sensors. 2021, 6, 3, 1330–1338
5. 5. Hu-Hu Han, Hai-Tao Zhang, Ru Wang, Yi Yan, Xiaoyan Liu, Yinye Wang, Yuanjun Zhu*, Jian-Cheng Wang*. Improving long circulation and procoagulant platelet targeting by engineering of hirudin prodrug.International Journal of Pharmaceutics 589 (2020) 119869
6. 6. Brittany Bodnar#, Arianna DeGruttola#, Yuanjun Zhu#, Yuan Lin, Yonggang Zhang, Xianming Mo, Wenhui Hu*. Emerging role of NIK-IKK2-binding protein (NIBP) Trafficking protein particle complex 9 (TRAPPC9) in nervous system diseases.Translational Research. 2020,224:55-70.
7. 7. Yuanjun Zhu#, Tongliang Zhou#, Lingfei Yang, Lan Yuan, Lei Liang*, Ping Xu*. Revelation of the dynamic progression of hypoxia-reoxygenation injury by visualization of the lysosomal hydrogen peroxide. Biochemical & Biophysical Research Communication, 2017, 486 (4):904-908.
8. 8. Tongliang Zhou, Lingfei Yang, Lei Liang*, Hui Liu,Yuanjun Zhu*, Mengyang Shui, Lan Yuan*, Fengrong Xu, Yan Niu, Chao Wang, and Ping Xu*. Rational Design of a Near-infrared Fluorescent Probe Based on Pyridazinone Scaffold. European Journal of Organic Chemistry. 2017, 3274–3281.
9. 9. Yuanjun Zhu#, Yuan Lin#, Xiaoyan Liu, Wenhui Hu*, Yinye Wang*. Identification of AcAP5 as a novel factor Xa inhibitor with both direct and allosteric inhibition. Biochemical and Biophysical Research Communications, 2017, 483(1):495-501.
10. 10. Yuanjun Zhu#, Yuanqing Gao#, Danping Zheng#, Mengyang Shui, Kuai Yu, Xiaoyan liu, Yuan Lin, Li Su, Wenxing Yang, Yinye Wang*. Design and evaluation of EphrinA1 mutants with cerebral protective effect. Scientific Reports, 2017; 7: 1881.
11. 11. Yuanjun Zhu#, Mengyang Shui#, Xiaoyan Liu, Wenhui Hu*, Yinye Wang*. Increased autophagic degradation contributes to the neuroprotection of hydrogen sulfide against cerebral ischemia/reperfusion injury. Metabolic Brain Disease, 2017, doi: 10.1007/s11011-017-0014-4.
12. 12. Yuanjun Zhu#, Ruyi Li#, Yuan Lin, Mengyang Shui, Xiaoyan Liu, Huan Chen, Yinye Wang*. Engineering Factor Xa Inhibitor with Multiple Platelet-Binding Sites Facilitates its Platelet Targeting. Scientific Reports. 2016, 6: 29895.
13. 13. Mengyang Shui, Xiaoyan Liu, Yuanjun Zhu*, Yinye Wang*. Exogenous hydrogen sulfide attenuates cerebral ischemia-reperfusion injury by inhibiting autophagy in mice. Canadian Journal of Physiology and Pharmacology, 2016, 94(11): 1187-1192.
14. 14. Lingfei Yang#, Yuanjun Zhu#, Mengyang Shui, Tongliang Zhou, Yuanbo Cai, Wei Wang, Fengrong Xu, Yan Niu, Chao Wang, Ping Xu*, Lan Yuan*, Lei Liang*. Rational Design of Fluorescent Phthalazinone Derivatives for One- and Two-Photon Imaging. Chemistry - A European Journal. 2016, 22(35):12363-70.
15. 15. Yuanjun Zhu#, Yuan Lin, Aihua Liu, Mengyang Shui, Ruyi Li, Xiaoyan Liu, Wenhui Hu, Yinye Wang*. Structure-guided creation of AcAP5-derived and platelet targeted factor Xa inhibitors. Biochemical Pharmacology. 2015, 95(4):253-62.
16. 16. Yuanjun Zhu#, Qixin Bu#, Xiaoyan Liu, Wenhui Hu, Yinye Wang*. Neuroprotective Effect of TAT-14-3-3 epsilon Fusion Protein against Cerebral Ischemia/Reperfusion Injury in Rats. PLoS One. 2014, 9(3): e93334.
17. 17. Yuanjun Zhu#, Aihua Liu#, Xiaoyan Liu, Yinye Wang*. Engineering Novel Anticoagulant Proteins by Motif Grafting. Protein and Peptide Letters. 2014, 21(2):159-63.