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余四旺

作者：  来源：  发布日期：2018年01月19日

 

 

余四旺，男，理学博士，北京大学药学院分子与细胞药理学系副教授，博士生导师。Current Pharmacology Reports（Springer）和Journal of Chinese Pharmaceutical Sciences编委，中华预防医学会肿瘤预防与控制专业委员会、中国抗癌协会抗癌药物专业委员会/肝癌专业委员会、中国药理学会肿瘤药理专业委员会等专委会委员，美国癌症研究协会（AACR）和中国化学会会员，国内外多个学术期刊长期通讯审稿人。曾获北京大学绿叶生物医药杰出青年学者奖、北京大学优秀人才奖励计划青年学者奖等。作为课题负责人和主要骨干承担或参与国家自然科学基金、科技部、教育部等国家级科研项目多项；已发表科研论文70篇，被引超过2000次；主编《癌症化学预防》专辑一部，参编英文专著两部，中文专著两部；曾负责组织了癌症化学预防前沿香山会议和多次北京大学癌症化学预防论坛等学术会议。

联系方式

北京市海淀区学院路38号，北京大学药学院，药学楼/卫生楼114，100191

北京市中关村生命科学园生命园路8号北大医疗产业园13#-421/528/B114，102206

实验室电话：（010）82805140；email：swang_yu@hsc.pku.edu.cn

研究兴趣

余四旺课题组主要围绕机体和细胞的应激信号转导机制，运用多种化学和分子、细胞、动物模型等手段，结合临床样本和数据，研究癌症及相关代谢性疾病发生发展、预防和治疗中的细胞与分子机制以及相应的生物标志物和干预靶标；进而在个体化预测疾病发生发展转归的基础上，发现和利用天然或合成的化学或生物物质对关键病理环节进行针对性干预或预防性治疗，并探索这些物质的作用机制。

招生招聘

欢迎志趣相投的本科生、研究生和博士后加入本课题组！

本课题组长期招聘博士后，待遇参照北京大学医学部博士后管理规定，并提供绩效奖励。

本课题组设备设施完备，管理规范，运行良好，气氛和谐积极向上，为成员提供了优良的学习和研究条件。实验室拥有多功能酶标仪、超灵敏多功能成像仪、实时荧光定量PCR仪、高速冷冻离心机、超低温冰箱、小鼠独立通气笼系统（IVC）、II级生物安全柜、超净工作台、低氧及普通CO2培养箱、倒置荧光显微镜、制冰机等仪器设备，和独立的SPF级动物实验室、洁净细胞培养室、药理实验室、分子生物学实验室等设施；已建立多种基因修饰小鼠模型和细胞模型，具备从分子、细胞到整体动物的系统研究能力。本课题组和兄弟课题组及临床科室合作顺畅，同时也有良好的国际合作和横向合作，已有两名博士生在双边合作协议和教育部支持下先后赴美国交流学习。此外，本课题组的大学生创新实验项目获得了药学院第一个医学部一等奖。

受教育经历

2000.9 –2003.12，北京大学药学院化学生物学系，博士，王夔教授，杨晓达教授

1997.9 –2000.7，华中科技大学化学系，硕士，徐辉碧教授，刘长林教授

1992.9 –1996.7，四川轻化工学院化学工程系，学士，王曙教授

研究工作经历

2018.1至今，北京大学药学院分子与细胞药理学系，副教授，博士生导师

2008.12 - 2017.12，北京大学药学院化学生物学系，副教授，硕士生导师

2004.12 –2008.12，美国Rutgers, The State University of New Jersey，博士后

2003.12 -2004.12，成都新康药业有限公司，总经理助理

1996.7 –1997.7，四川广康化纤股份有限公司，助理工程师

主要论著

期刊论文：

  1. Cao M, Wang H, Guo L, Yang S, Liu C, Khor TO, Yu S*, Kong AN. Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling. AAPS J. 2017;19(6):1703-1714
  2. Cheng W, Liu Z, Yu Y, van Ofwegen L, Proksch P, Yu S*, Lin W*, An unusual spinaceamine-bearing pregnane from a soft coral Scleronephthya sp. inhibits the migration of tumor cells, Bioorg Med Chem Lett, 2017;27(12):2736-2741
  3. Ji L, Yang S, Li S, Liu S, Tang S, Liu Z, Meng X*, Yu S*, A novel triazolonaphthalimide induces apoptosis and inhibits tumor growth by targeting DNA and DNA-associated processes, Oncotarget, 2017;8(23):37394-37408
  4. Ji S, Tang S, Li K, Li Z, Liang W, Qiao X, Wang Q, Yu S*, Ye M*, Licoricidin inhibits the growth of SW480 human colorectal adenocarcinoma cells in vitro and in vivo by inducing cycle arrest, apoptosis and autophagy, Toxicol Appl Pharmacol, 2017;326:25-33
  5. Li K, Ji S, Song W, Kuang Y, Lin Y, Tang S, Cui Z, Qiao X, Yu S, Ye M*, Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra, J Nat Prod, 2017;80(2):334-346
  6. Que L, He L, Yu C, Yin W, Ma L, Cao B*, Yu S*, Activation of Nrf2-ARE signaling mitigates cyclophosphamide-induced myelosuppression, Toxicol Lett, 2016; 262:17-26
  7. Zhao, Y., Liu, D., Proksch, P., Yu, S.*, Lin, W.*, Isocoumarin Derivatives from the Sponge-Associated Fungus Peyronellaea glomerata with Antioxidant Activities, Chem Biodivers, 2016 Jul 23. doi: 10.1002/cbdv.201600012
  8. Yang, J., Yang, S., Zhou, S., Lu, D., Ji, L., Li, Z., Yu, S.*, Meng, X.*, Synthesis, anti-cancer evaluation of benzenesulfonamide derivatives as potent tubulin-targeting agents, Eur J Med Chem. 2016 Oct 21;122:488-496
  9. Wu ZH, Wang YR, Liu D, Proksch P, Yu SW*, Lin WH*. Antioxidative phenolic compounds from a marine-derived fungus Aspergillus versicolor. Tetrahedron. 2016; 72(1):50-57.
  10. Ji S, Li Z, Song W, Wang Y, Liang W, Li K, Tang S, Wang Q, Qiao X, Zhou D, Yu S*, Ye M*. Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine. J Nat Prod. 2016;79(2):281-292.
  11. Yu S*, Yang CS, Li J, You W, Chen JG, Cao Y, Dong Z, Qiao YL, Cancer Prevention Research in China, Cancer Prev Res (Phila), 2015, 8(8):662-74 (Cover story)
  12. Guo Y, Yu S*, Zhang C, Tony Kong AN, Epigenetic regulation of Keap1-Nrf2 signaling, Free Radic Biol Med, doi:10.1016/j.freeradbiomed.2015.06.013
  13. Ji S, Li R, Wang Q, Miao WJ, Li ZW, Si LL, Qiao X, Yu SW, Zhou DM, Ye M, Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis. J Ethnopharmacol. 2015 Nov 11. pii: S0378-8741(15)30221-X.
  14. Zhang C, Zhong B, Yang S, Pan L, Yu S, Li Z, Li S, Su B, Meng X, Synthesis and biological evaluation of thiabendazole derivatives as anti-angiogenesis and vascular disrupting agents, Bioorg Med Chem, 2015, 23(13):3774-80
  15. Yang SM, Ji LY, Que LL, Wang K, Yu SW*, Metformin activates Nrf2 signaling and induces the expression of antioxidant genes in skeletal muscle and C2C12 myoblasts, J Chin Pharma Sci, 2014, 23(12):837-43
  16. Jian Bai, Dong Liu, Siwang Yu, Peter Proksch, Wenhan Lin, Amicoumacins from the marine-derived bacterium Bacillus sp. with the inhibition of NO production, Tetrahedron Letters, 2014, 55(45):6286–6291
  17. Yang J, Zhou S, Ji L, Zhang C, Yu S, Li Z, Meng X, Synthesis and structure-activity relationship of 4-azaheterocycle benzenesulfonamide derivatives as new microtubule-targeting agents, Bioorg Med Chem Lett, 2014, 24(21):5055-5058
  18. Lou Q, Ji L, Zhong W, Li S, Yu S*, Li Z, Meng X*, Synthesis and cytotoxicity evaluation of naphthalimide derived N-mustards, Molecules, 2014, 19(7):8803-19
  19. Lin XH, Cao MN, He WN, Yu SW*, Guo DA, Ye M*, Biotransformation of 20(R)-panaxadiol by the fungus Rhizopus chinensis, Phytochemistry, 2014, 105:129-34
  20. Ma WW, Tang SN, Cao MN, Ge ZM, Li RT, Yu SW*, IC5, a dithiocarbamate derivative, inhibits colon cancer cell proliferation in vitro and colitis-associated colorectal carcinogenesis in vivo, J Chin Pharma Sci, 2014, 23(9): 610-6
  21. Huang W, Tang S, Qiao X, Ma W, Ji S, Wang K, Ye M*, Yu S*，Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupt- ing mitochondrial functions, Fitoterapia, 2014, doi: 10.1016/j.fitote.2014.01.016.
  22. Que LL, Wang XZ, Qian PZ, Cao BS, Wang K, Yu SW*, Upregulation of Nrf2 regulated gene expression by tBHQ alleviates cyclophosphamideinduced hematotoxicity in mice, J Chin Pharma Sci, 2014, 23(1): 39-45
  23. Qiao X, Ji S, Yu SW, Lin XH, Jin HW, Duan YK, Zhang LR, Guo DA, Ye M*, Identification of Key Licorice Constituents Which Interact with Cytochrome P450: Evaluation by LC/MS/MS Cocktail Assay and Metabolic Profiling, AAPS J, 2014, 16(1):101-13
  24. Wu TY, Khor TO, Su ZY, Saw CL, Shu L, Cheung KL, Huang Y, Yu S, Kong AN, Epigenetic Modifications of Nrf2 by 3,3'-diindolylmethane In Vitro in TRAMP C1 Cell Line and In Vivo TRAMP Prostate Tumors, AAPS J, 2013, 15(3): 864-74
  25. 余四旺*，杨中枢，癌症化学预防在中国，化学进展，2013, 25(9): 1411-4
  26. Kim JH,Yu S, Chen JD, Kong AN*, The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains, Oncogene, 2013;32(4): 514-27
  27. Gao Z, Zhang C, Yu S*, Yang X*, Wang K, Vanadyl bisacetylacetonate protects β cells from palmitate-induced cell death through the unfolded protein response pathway, J Biol Inorg Chem. 2011;16(5):789-98
  28. Que LL, Wang HX, Cao BS, Yang XD, Wang K, Yu SW*, The regulation and functions of transcription factor Nrf2 in cancer chemoprevention and chemoresistance, J Chin Pharm Sci 2011 20 (1): 5-19
  29. Yu S, Khor TO, Cheung K-L, Li W, Wu T-Y, Huang Y, Foster BA, Kan YW, Kong AN*, Nrf2 Expression Is Regulated by Epigenetic Mechanisms in Prostate Cancer of TRAMP Mice. PLoS One. 2010 Jan 5;5(1):e8579
  30. Khor TO*, Yu S*, Barve A, Hao X, Hong JL, Lin W, Foster B, Huang MT, Newmark HL, Kong AN., Dietary Feeding of Dibenzoylmethane (DBM) Inhibits Prostate Cancer in Transgenic Adenocarcinoma of the Mouse Prostate Model, Cancer Res, 2009, 69:7096-102
  31. Yu S, Shen G, Khor TO, Kim JH, Kong AN., Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism, Mol Cancer Ther, 2008, 7:2609-20
  32. Yu, S., Kong, A.N., Targeting carcinogen metabolism by dietary cancer preventive compounds, Curr Cancer Drug Targets, 2007, 7:416-424
  33. Li, W.*, Yu, S.* & Kong, A.N., Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain, J Biol Chem, 2006, 281:27251-27263
  34. Yu, S., Hu, J., Yang, X., Wang, K. & Qian, Z.M., La(3+)-induced extracellular signal-regulated kinase (ERK) signaling via a metal-sensing mechanism linking proliferation and apoptosis in NIH 3T3 cells, Biochemistry, 2006, 45:11217-11225
  35. Yu, S., Yuan, L., Yang, X., Wang, K., Ke, Y. & Qian, Z.M., La3+-promoted proliferation is interconnected with apoptosis in NIH 3T3 cells, J Cell Biochem, 2005, 94:508-519

专著：

  1. 余四旺，杨中枢，癌症化学预防研究前沿，《2014科学发展报告》，中国科学院编，科学出版社，2014.3，ISBN978-7-03-039834-5
  2. 余四旺，微量元素化学生物学，《中国学科发展战略化学生物学》，张礼和等，科学出版社，2014
  3. 余四旺，杨中枢，癌症化学预防专辑，《化学进展》编辑部，16万字，2013
  4. Wang K, Yu S and Zhang T, Arsenic in Traditional Chinese Medicine, p113 – 133, in Biological Chemistry of Arsenic, Antimony and Bismuth, edited by Dr. Hongzhe Sun, 2011 John Wiley & Sons, Inc., ISBN: 978-0-470-71390-7
  5. Yu S, Cheung KL, Li W and Kong ANT, Plant Phenolic Compounds - modulation of cytoprotective enzymes and Nrf2/ARE signaling, p402-426, in Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology, edited by Dr. Cesar G Fraga，2009 John Wiley & Sons, Inc., ISBN: 978-0-470-28721-7

 

专利：

  1. 余四旺，叶敏等，一种异戊烯基黄酮类化合物的药物新用途，ZL201210348167.8，中国专利，授权
  2. 叶敏，余四旺等，刺甘草査尔酮的新用途，CN105232501A，中国专利
  3. 叶敏，余四旺等，甘草中一类异戊烯基异黄酮类化合物的医药新用途，201510918824.1，中国专利

 

课题组活动照片

       

 

 

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