We undertook many kinds of scientific research projects, including National Science and Technology projects,"973" and"863" projects, National Natural Science Fund projects, The Ministry of Education projects such as "211" and"985" projects, Ministry of Education and Cultivation of Innovative Team Fund, Significant New Drugs Creation" major projects from National Science and Technology ," Eleventh-Five" Integrated Platform and other topics during the" eighth-five" to the"13th Five-Year Plan". In past 10 years, we applied a series of Chinese and international patents, and published nearly 100 papers in high-profile journals, including Science, Cell Chemical Biology, JACS and Nature Communications.