Ph.D.
Research Areas
Pharmacology
Education & Positions:
Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, doctor, 2007-2010
Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, lecturer 2010-
Research Interests:
1. Target based pharmacodynamics and mechanisms of new drugs in the central nervous system.
2. Establishment of liver fibrosis model and study on liver protective effect of Chinese herbal medicine.
3. Proteomics study of methamphetamine addiction
Grants and fundings :
1. National Natural Science Foundation of China.
Anti-PD effects of 3-ODS and the molecular mechanisms of 3-ODS mainly based on reducing oxidative stress and the relationship with DJ-1. (RMB 230,000)
Principal Investigator
2. Interdisciplinary medicine Seed Fund of Peking University.
Establishment of brain extracellular space delivery method and evaluation of the effect of cohosh on cerebral ischemia reperfusion injury. (RMB 100,000)
Principal Investigator
3. Opening Foundation of Key Laboratory of Chinese Academy of Sciences.
Preclinical pharmacodynamic evaluation of the role of Majun Mupakhi ELA in invigorating Yang. (RMB 120,000)
Principal Investigator
4. Opening Foundation of Key Laboratory of Chinese Academy of Sciences.
Effects of Majun Mupakhi ELA on repeated stress and diabetes induced erectile dysfunction. (RMB 100,000)
Principal Investigator
Publications:
1. Zheng XY#, Zhao X#, Yang YF, Jiang HJ, Li W, Sun Y, Pu XP*. Antioxidant, antiapoptotic and amino acid balance regulating activities of 1,7-dihydroxy-3,4,8-trimethoxyxanthone against dimethylnitrosamine-induced liver fibrosis. PLoS One. 2017, 12(12): e0189344.
2. Zhang Z, Liu R, Pu X, Sun Y, Zhao X*. Evaluation of the sub-chronic toxicity of a standardized flavonoid extract of safflower in rats. Regul Toxicol Pharmacol. 2017, 85:98-107.
3. Zhao X, Zhai S, An MS, Wang YH, Yang YF, Ge HQ, Liu JH, Pu XP*. Neuroprotective effects of protocatechuic aldehyde against neurotoxin-induced cellular and animal models of Parkinson's disease. PLoS One. 2013, 8(10):e78220.
4. Shi WL#, Zhao X#, Liu ZM, Zhang M, Zhou BY, Pu XP*. Serum proteomics of methamphetamine addicts and up-regulation of complement factor H related to methamphetamine addiction. Neurosci Lett. 2012, 525(1):23-8.
5. Xin Zhao, Shiping Zhang, Chunna An, Hongning Zhang, Yi Sun, Yanmei Li, Xiaoping Pu*. Neuroprotective effect of fucoxanthin on β-amyloid-induced cell death. J. Chin. Pharm. Sci. 2015, 24 (7), 467-474.
6. Yongfei Guo, Chen Wang, Wan Li, Ke Zhang, Hui Lei, Yi Sun, Xiaoping Pu*, Xin Zhao*. Neuroprotective effects of xanthones extract of Swertia punicea Hemsl against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of parkinson’s disease. J Chin Pharm Sci.2016, 25 (5): 357-365.
