Professor of Neuropsychopharmacology

                             Psychiatrist (Doctor's License No:19991111)

Address

Department of Molecular and Cellular Pharmacology

School of Pharmaceutical Sciences

Peking University

38 Xue Yuan Road, Haidian District

Beijing 100191, P. R. China

Tel： (8610) 82802452 (office)

         (8610) 82756271 (home)

Mobile： (8610) 13520380859

E-mail： liangjh@bjmu.edu.cn/liangjh@pku.edu.cn

Academic member

Founder/Regular member：Asian Pacific Society for Alcohol and Addiction Research (APSAAR) (2009 to present)

Secretary-General：Division of Neuropyschoharmacology, Chinese Pharmacological Society (2005 to present)

Vice Chair： Division of Neuropsychopharmacology, Beijing Pharmacological Society (2011 to present)

Deputy Chief Editor： Metabolic Brain Disease (2015 to present)

 Research field： Neuropsychopharmacology

(1) Behavioral plasticity induced by psychoactive substance and Chaperone-mediated opioid addiction in rats, mice, and zebra fishes.

(2) Anti-alcoholism of extracts, fractions and compounds from Traditional Chinese medicine and the mechanism underlying their pharmacological profiles in alcohol-preferring rats and mice.

(3) A new model of comorbidity between depression and anxiety induced by Liang's contextual-stress box and the pathophysiological mechanisms in mice.

 Main publication:

1. Qin WJ, Wang YT, Li PM, Wang XX, Li JX, Noori HR, Bernardi RE, Liang JH*, Zhang XL*. Context- and time-dependent neurobiological and behavioral sensitization induced by a single morphine exposure in mice. Psychopharmacology (Berl). 2016 Apr; 233(7):1147-55.doi: 10.1007/s00213- 015-4197-2.
2. Wen RT, Feng WY, Liang JH*, Zhang HT*. Role of phosphodiesterase 4-mediated cyclic AMP signaling in pharmacotherapy for substance dependence. Curr Pharm Des. 2015;21(3):355-64.
3. Gao JL, Tu SA, Liu J, Zhang JM, Huang Y, Han M, Liang JH*. An-jun-ning, a traditional herbal formula, attenuates spontaneous withdrawal symptoms via modulation of the dopamine system in morphine-dependent rats.BMC Complement Altern Med. 2014 Aug 19;14:308. doi: 10.1186/1472-6882-14-308.
4. Yu-ling LI, Qing LIU, Qi GONG, Jun-xu LI, Shou-peng WEI, Yan-ting WANG, Hui LIANG, Min ZHANG, Li JING, Zheng YONG, Andrew J. LAWRENCEand Jian-hui LIANG*, The glycine receptor antagonist brucine decreases ethanol  intake and preference  in alcohol-preferring Fawn-Hooded rats. Acta Pharmacol Sin. 2014 Jul;35(7):853-61. doi: 10.1038/aps.2014.28. Epub 2014 Jun 9.
5. Jing L, Zhang M, Li JX, Huang P, Liu Q, Li YL, Liang H, Liang JH*. Comparison of single versus repeated methamphetamine injection induced behavioral sensitization in mice. Neurosci Lett. 2014 Feb 7;560:103-6. doi: 10.1016/j.neulet.2013.12.024. Epub 2013 Dec 19.
6. Yan-Ting Wang, Wang-Jun Qin, Qing Liu, Yu-Ling Li, Hui Liang, Feng Chen, Andrew J. Lawrence and Jian-Hui Liang*. Chaperone heat shock protein 70 in nucleus accumbens core: a novel biological target of behavioural sensitization to morphine in rats. Int J Neuropsychopharmacol. 2014. 17(3): p. 469-84. doi:10.1017/S1461145713001429 .
7. Qin WJ, Wang YT, Zhang M, Wen RT, Liu Q, Li YL, Chen F, Lawrence AJ, Liang JH*. Molecular chaperone heat shock protein 70 participates in the labile phase of the development of behavioural sensitization induced by a single morphine exposure in mice. Int J Neuropsychopharmacol. 2013(16):647-659. Epub 2012 May 30:1-13. doi:10.1017/S1461145712000557 [Epub ahead of print] .
8. Wen RT, Zhang M, Qin WJ, Liu Q, Wang WP, Lawrence AJ, Zhang HT, Liang JH*. The Phosphodiesterase-4 (PDE4) Inhibitor Rolipram Decreases Ethanol Seeking and Consumption in Alcohol-Preferring Fawn-Hooded Rats. Alcohol Clin Exp Res. 2012 Dec;36(12):2157-67. doi: 10.1111/j.1530-0277.2012.01845.x. Epub 2012 Jun 4.
9. Zhang M, Jing L, Liu Q, Wen RT, Li JX, Li YL, Gong Q, Liang JH*. Tramadol induces conditioned place preference in rats: Interactions with morphine and buprenorphine. Neurosci Lett. 2012 Jun 27;520(1):87-91. Epub 2012 May 22.
10. Qing Liu, Min Zhang, Wang-Jun Qin, Yan-Ting Wang, Yu-Ling Li1, Li Jing, Jun-Xu Li, Andrew J. Lawrence, Jian-Hui Liang* Septal Nuclei Critically Mediate the Development of Behavioral Sensitization to a Single Morphine Injection in Rats.Brain Res. 2012 May 15;1454:90-9.
11. Qing Liu, Wang-Jun Qin, Min Zhang, Yan-Ting Wang, Li Jing, Jun-Xu Li,Jian-Hui Liang*. Morphine attenuates frustration-like behavior induced by sucrose reward deprivation in rats.Neural Regen Res. 2011;6(28):2211-2216.
12. Jing L, Luo J, Zhang M, Qin WJ, Li YL, Liu Q, Wang YT, Lawrence AJ,Liang JH*. Effect of the histone deacetylase inhibitors on behavioural sensitization to a single morphine exposure in mice. Neurosci Lett. 2011 Mar 22. 494 (2011) 169–173 [Epub ahead of print] PMID: 21396430. DOI:10.1016/j.neulet.2011.03.005.
13. Qing Liu, Andrew J. Lawrence, Jian-hui Liang*. Traditional Chinese medicine for treatment of alcoholism: from ancient to modern. Am J Chin Med. 2011;39(1):1-13. DOI: 10.1142/S0192415X11008609.
14. Luo J, Jing L, Qin WJ, Zhang M, Lawrence AJ, Chen F, Liang JH*. Transcription and protein synthesis inhibitors reduce the induction of behavioural sensitization to a single morphine exposure and regulate Hsp70 expression in the mouse nucleus accumbens. Int J Neuropsychopharmacol. 2011 Feb;14(1):107-21. Epub 2010 Jun 2. doi:10.1017/S146114571000057X PMID: 20519062 [PubMed - in process].
15. Sun YP, Liu Q, Luo J, Guo P, Chen F, Lawrence AJ, Liang JH*. Systemic Administration of Arecoline Reduces Ethanol-Induced Sleeping Through Activation of Central Muscarinic Receptor in Mice. Alcohol Clin Exp Res. 2010 (January), 34(1): 150 – 157; Published Online: Oct 23 2009 4:25PM, DOI: 10.1111/j.1530-0277.2009.01076.x
16. Jian-Hui Liang,Feng Chen, Michael S. Cowen, Fiona Y. Carroll, Duncan Crawford, Philip M. Beart, Andrew J. Lawrence*. The GABAB receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats. Neuropharmacology. 2006 Apr; 50(5):632-9.
17. Jian-Hui Liang*,Keng Wang, Hong-Lei Sun, and Rong Han. Potentiating effect of tramadol on methamphetamine-induced behavioral sensitization in mice. Psychopharmacology (Berl). 2006 Mar; 185(1):1-10.
18. Li JX, Han R, Deng YP, Chen SQ, Liang JH* Different effects of valproate on methamphetamine- and cocaine-induced behavioral sensitization in mice. Behav Brain Res. 2005 Jun 3;161(1):125-32.
19. Wen-Li Zhao, Ze-Hui Gong,Jian-Hui Liang*. A new buprenorphine analogy, thenorphine, inhibits morphine-induced behavioral sensitization in mice.Acta Pharmacol Sin. 2004, November; 25 (11): 1413-1418.
20. Li JX, Zhao WL,Liang JH*. Effects of carbamazepine on morphine-induced behavioral sensitization in mice. Brain Res. 2004 Sep 3; 1019(1-2):77-83.
21. Li JX, Zhang Q, Liang JH*. Valproate prevents the induction, but not the expression of morphine sensitization in mice. Behav Brain Res. 2004 Jul 9; 152(2):251-7.
22. Liang JH*,Li JX, Wang XH, Chen B, Lu Y, Zhang P, Han R, Ye XF. L-type calcium channel blockers enhance 5-HTP-induced antinociception in mice. Acta Pharmacol Sin. 2004 May; 25(5):644-50.
23. Zhou JL, Liang JH*, Zheng JW, Li CL.  Nerve growth factor protects R2 cells against neurotoxicity induced by methamphetamine. Toxicol Lett. 2004 Apr 21;150(2):221-7.
24. Ye XF, Lu Y, Zhang P, Liang JH*. Calmodulin inhibitor trifluoperazine attenuates the development and expression of morphine-induced conditioned place preference in rats. Eur J Pharmacol. 2004 Feb 23;486(3):265-71.
25. Zhang Q, Li JX, Zheng JW, Liu RK, Liang JH*. L-type Ca (2+) channel blockers inhibit the development but not the expression of sensitization to morphine in mice. Eur J Pharmacol. 2003 Apr 25;467(1-3):145-50.
26. Liang JH*, Wang XH, Liu RK, Sun HL, Ye XF, Zheng JW.  Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in mice. Psychopharmacology (Berl). 2003 Mar;166(3):276-83.
27. Sun HL, Zheng JW, Wang K, Liu RK, Liang JH*.  Tramadol reduces the 5-HTP-induced head-twitch response in mice via the activation of mu and kappa opioid receptors. Life Sci. 2003 Jan 31;72(11):1221-30.