Ph.D, Associate Professor

Research Areas:
Molecular Pharmacology
 

Education & Positions:

ShanDong Normal University, B.S, 1992
Peiking University, Ph.D, 2013
Ji Ning Medical college, Lecturer, 1992-1999
Peiking University, Lecturer, 2002-2016
Peiking University, Associate Professor, 2016-
University of Michigan, Visiting Scholar, 2017-2018

Faculty Accolades:

Peiking University Prominent Teacher, 2009
Peiking University Health Science Center Excellent Young Teacher, 2014
 

Research Interests:

My research focuses on the molecular mechanism of small-molecule inhibitor for manipulation of Virus-Host recognition. We found that triterpenes interrupt the interaction between HCV envelope protein E2 and its receptor CD81 via binding to E2, thus blocking virus and host cell recognition. This study establishes the importance of triterpene natural products as new leads for the development of potential HCV entry inhibitors. Now I also study virus single viron partical fluorescent tracking and the interaction process of Virus-Host cell with the genetic code expansion technology.

Grants and fundings:

Inditification of receptors for VSV based on "genetic code expansion technology " (National Natural Science Foundation of China, 81101239, RMB 250,000)
Studies of Ebola virus single viron partical fluorescent tracking and the interaction process of virus-host cell (National Natural Science Foundation of China, 81572004, RMB 750,000), Principal Investigator
 

Selected Publications:

1. Fei Yu#，Qi Wang#，Zhen Zhang，Yiyun Peng，Yunyan Qiu，Yongying Shi，Yongxiang Zheng，Sulong Xiao，Han Wang，Xiaoxi Huang，Linyi Zhu，Kunbo Chen，Chuanke Zhao，Chuanling Zhang，Maorong Yu，DianSun，Lihe Zhang，Demin Zhou*，Development of oleanane-type triterpenes as a new class of HCV entry inhibitors，Journal of Medicinal Chemistry，2013，56（11）：4300-4319.(Co-first author)
2.Han Wang#，Qi Wang#，Su-Long Xiao，Fei Yu，Min Ye，Yong-Xiang Zheng，Chuan-Ke Zhao，Di-An Sun，Li-He Zhang，De-Min Zhou*，Elucidation of the pharmacophore of echinocystic acid, a new lead for blocking HCV entry，European Journal of Medicinal Chemistry，2013，68：160-168 (Co-first author)
3.Fei Yu#，Yiyun Peng#，Qi Wang#，Yongying Shi，Longlong S，Han Wang，Yongxiang Zheng，EmilyLee，Sulong Xiao，Maorong Yu，Yingbo Li，Chuanling Zhang，Hengli Tang，Chunguang Wang，LiheZhang，Demin Zhou*，Development Of bivalent oleanane-type triterpenes as potent HCV entry inhibitors，European Journal of Medicinal Chemistry，2014，77（2014）：258-268. (Co-first author)
4. Sulong Xiao#，Qi Wang#，Fei Yu，Yiyun Peng，Ming Yang，Matthieu Sollogoub，Pierre Sina？，Yongmin Zhang，Lihe Zhang，Demin Zhou*，Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors，Bioorganic & Medicinal Chemistry，2012，2012（12）：5616-5622 (Co-first author).
5. Yongxiang Zheng, Fei Yu, Yiming Wu, Longlong Si, Huan Xu, Chuanling Zhang, Qing Xia, Sulong Xiao, Qi Wang, Qiuchen He, Peng Chen, Taira K, Lihe Zhang，Demin Zhou*, Broadening the versatility of lentiviral vectors as a tool in nucleic acid research via genetic code expansion. Nucleic Acids Res. 2015 Jun 23; 43(11): e73.