Ph.D.

Research Areas
Molecular Pharmacology
Ion Channel Drugs
 

Education & Positions:

Beijing Medical University School of Pharmaceutical Sciences, Pharmacology, Bachelor of Science, 1994-1999
Peking University School of Pharmaceutical Sciences, Pharmacology, Master of Science, 2002-2005
Peking University School of Pharmaceutical Sciences, Pharmacology, Doctor of Science, 2013-2017
Peking University School of Pharmaceutical Sciences, Pharmacology, Assistant Teacher, 1999-2004
Peking University School of Pharmaceutical Sciences, Pharmacology, Lecturer, 2004-
University of Virginia, school of medicine, Visiting Scholar, 2011-2012
 

Faculty Accolades:

Peking University Health Science Center Excellent Teacher Award 2015
Peking University Health Science Center Education and Teaching Achievement Award 2017
 

Research Interests

Our overall research is directed towards understanding molecular mechanisms of ion channels, and their modulations in pain, epilepsy, and cancer. Using techniques of electrophysiology, molecular biology and proteomics, our recent efforts have focused on studying molecular mechanism of calcium-activated chloride channel ANO1/TMEM16A in cancer and identification/development of ANO1 modulators.

Selected Publications

1. 1. Song, Y.; Gao, J.; Guan, L.Z.; Chen, X.L.; Gao, J.J.; Wang, K.W.*. Inhibition of ANO1/TMEM16A induces apoptosis in human prostate carcinoma cells by activating TNF-α signaling. Cell Death Dis. 2018 Jun 13;9(6):703.
2. 2. Santen, R.J.; Song, Y.; Wang, J.P.; Yue, W.*. Preclinical breast effects of a tissue selective estrogen complex (TSEC) including conjugated estrogen with bazedoxifene. J Steroid Biochem Mol Biol. 2017 Jun;170:61-64.
3. 3. Guan, L.Z.; Song, Y.; Gao, J.; Gao, J.J; Wang, K.W.*. Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells. Oncotarget. 2016,7(48):78619-78630.
4. 4. Teng, B.C.#; Song, Y.#; Zhang, F.; Ma, T.Y.; Qi, J.L.; Zhang, H.L.; Li, G.*; Wang, K.W.*. Activation of neuronal Kv7/KCNQ/M-channels by the opener QO58-lysine and its anti-nociceptive effects on inflammatory pain in rodents. Acta Pharmacologica Sinica. 2016,37(8): 1054–1062.
5. 5. Song, Y.; Santen, R.J.; Wang, J.P.; Yue, W.*. Inhibitory effects of a bazedoxifene/conjugated equine estrogen combination on human breast cancer cells in vitro. Endocrinology 2013,154(2):656-665.