Professor
Research Areas:
Pharmacology
Pharmacology of Chinese Materia Medica
Education & Positions:
Zhejiang Xiaoshan TCM hospital, surgeon, 1984-1987
Shanghai University of Traditional Chinese Medicine, Doctor of Medicine, 1990-1993
Beijing Medical University, Postdoctoral Fellow, 1993-1995
Peking Union Medical College, Assistant Professor, 1995-1997
WHO Tokyo Metropolitan Institute of Gerontology. Investigator, 1997-1998
Sichuan Aba Health School, Lecturer, 1998-1999
Peking University. Lecturer, 1998-2000; Associate Professor, 2000-2016; Professor, 2016-
Research Interests:
1. To study novel antinociceptive mechanism that underlies acting peripheral ？7 nAChR and M4 mAChR and related signaling pathways. We have found that spirocyclopiperaziniumsalt compound LXM-10-M produced significant antinociceptive effect without obvious toxicity. The antinociceptive mechanism was mediated by activation of ？7 nicotinic receptor and M4 muscarinic receptor, and inhibition of CaMKIIα/CREB/CGRP signaling pathway.
2. To study novel anti-inflammatory mechanism underlying peripheral ？7 nAChR and M4 mAChR. We have reported that the spirocyclopiperazinium salt compound LXM-15 displays considerable anti-inflammatory effects. The underlying mechanism is through activating the peripheral ？7 nicotinic acetylcholine receptor and M4 muscarinic acetylcholine receptor, leading to the inhibition of the JAK2/STAT3 signalling pathway, resulting in the reduction of TNF-？ and IL-6.
3. To develop novel drugs against chronic neuropathic pain and inflammation with reduced side effects.
Grants and fundings:
1. The National Natural Science Foundation of China, China (Grant No.81470050), (RMB 300000) , 2015.1-2016.12 PI
2. The Beijing Municipal Natural Science Foundation, China (Grant No.7122097), (RMB 110000), 2014.1-2016.12 PI
Selected Publications:
1. Hua Yang, Qi Sun, Yingying Liang ,Yimin Jiang, Runtao Li, Jia Ye* Antinociception of the spirocyclopiperazinium salt compound LXM-15 via activating α7 nAChR and M4 mAChR and inhibiting CaMKIIα/cAMP/CREB/CGRP signalling pathway in mice Regulatory Toxicology and Pharmacology 2018, 94: 108–114
2. Xiaoli Gao, Qi Sun, Weiwei Zhang, Yimin Jiang，Runtao Li, Jia Ye* Anti-inflammatory effect and mechanism of the spirocyclopiperazinium salt compound LXM-15 in rats and mice Inflammation research 2018 67:363–370
3. Weiwei Zhang, Feng Xu, Ding Wang, Jia Ye*, Shaoqing Cai* Buyang Huanwu Decoction ameliorates ischemic stroke by modulating multiple targets with multiple components in vitro Chinese Journal of Natural Medicines 2018, 16（3）: 194–202
4. Dan Wan, Ding Wang, Qi Sun, Yan Song, YiMin Jiang, Runtao Li, JiaYe*. Antinociception of spirocyclopiperazinium salt compound LXM-10-M targeting α7 nicotinic receptor and M4 muscarinic recaptor and inhibiting CaMKIIα/CREB/CGRP signaling pathway in mice. European Journal of Pharmacology 770(2016) 92–98
5. Xiaoli Gao, Hua Yang,Yangguang Xu,Yulan Xiong, Guannan Wang, Xinshan Ye*, Jia Ye* Iminosugar derivative WGN-26 suppresses acute allograft rejection via inhibiting the IFN-γ/p-STAT1/T-bet signaling pathway International Immunopharmacology 2014, 23: 688–695
3. Weiwei Zhang, Qi Sun, Xiaoli Gao, Yimin Jiang, Runtao Li, Jia Ye*，Anti-Inflammation of Spirocyclopiperazinium Salt Compound LXM-10 Targeting a7 nAChR and M4 mAChR and Inhibiting JAK2/STAT3 Pathway in Rats. PLOS ONE 2013, 8(6):1-8 (8: e66895) (IF 4.015)
4. Xia Zhao, Jia Ye*, Qi Sun, Yulan Xiong, Runtao Li and Yimin Jiang Antinociceptive effect of spirocyclopiperazinium salt compound LXM-15 via activating peripheral α7 nAChR and M4 mAChR in mice. Neuropharmacology 2011, 60:446-452 (IF 5.106)
5. Song-Wen Lin, Qi Sun, Ze-Mei Ge, Xin Wang, Jia Ye*, Run-Tao Li* Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ). Bioorganic & Medicinal Chemistry Letters2011, 21: 940–943 ( IF 2.447)
6. Yulan Xiong, Xia Zhao, Qi Sun, Runtao Li, Changling Li, Jia Ye*，Antinociceptive mechanism of the spirocyclopiperazinium compound LXM-10 in mice and rats. Pharmacol. Biochem. Behav.2010, 95:192–197 (IF2.772)
7. Yulan Xiong, Jia Ye*, Qi Sun, Xia Zhao, Runtao Li, Yimin Jiang, Anti-inflammatory effect of the spirocyclopiperazinium compound LXM-10 in mice and rats. European Journal of Pharmacology2010, 626: 290–296 (IF 2.754)
8. Guo-Liang Zhang, Changshui Chen, Yulan Xiong, Jia Ye*，Xin-Shan Ye*，Synthesis of N-substituted iminosugar derivatives and their immunosuppressive activities. Carbohydrate Research 2010, 345: 780–786 (IF 2.148)
9. Deng-Bo Ji,Jia Ye*, Chang-Ling Li, Yu-Hua Wang, Jiong Zhao and Shao-Qing Cai Antiaging Effect of Cordyceps sinensis Extract. Phytotherapy Research 2009, 23:116–122 (IF2.48)
10. 10. Deng-Bo Ji, Jia Ye*, Yi-Min Jiang and Bo-Wen Qian Anti-tumor effect of Liqi, a traditional Chinese medicine prescription, in tumor bearing mice. BMC Complementary and Alternative Medicine2009, 9:20(IF 2.343)
11. Deng Bo Ji, Chang Ling Li, Jia Ye*, Hai Bo Zhu* Effect of Hydroxysafflor yellow A on Human Umbilical Vein Endothelial Cells under hypoxia. Vascular Pharmacology 2009, 50: 137–145 (IF 3.134)
12. Ji DB, Zhu MC, Zhu B, Zhu YZ, Li CL,Ye J*, Zhu HB*, Hydroxysafflor yellow A enhances survival of vascular endothelial cells under hypoxia via upregulation of the HIF-1 alpha-VEGF pathway and regulation of Bcl-2/Bax. J Cardiovasc Pharmacol 2008, 52 (2) :191-202 (IF2.243)
13. Deng Bo JI, Hai Bo ZHU, Jia YE*, Chang Ling LI* Establishment of a Cell-Based Assay to Screen Regulators of the Hypoxia-Inducible Factor-1-Dependent Vascular Endothelial Growth Factor promoter. Biol. Pharm. Bull. 2008, 31(12): 2255–2259 (IF 1.904)
14. Cai-Qin Yue, Jia Ye*, Chang-Ling Li, Run-Tao Li, Qi Sun. Antinociceptive effects of the novel spirocyclopiperazinium salt compound LXM -10 in mice. Pharmacol. Biochem. Behav. 2007, 86:643–650.(IF 2.772)
