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Pu Xiaoping

Ph.D., Professor

 

Title

Associate Director Department of Molecular and Cellular Pharmacology, -->-->School of Pharmaceutical Sciences, Peking University Health Science Center

Professor Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center

Doctoral Supervisor Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center

Contact

Telephone

+86-10-82802431

Fax

+86-10-82802431

Address

Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing100191, P.R. China

Email

pxp123@bjmu.edu.cn

Education

1978-1982 BSc Department of Pharmaceutical Sciences, Lanzhou Medical College, Gansu Province, P.R. China

1990-1992 MSc Faculty of Pharmaceutical Sciences, Hokkaido University, Japan

1992-1995 PhD Faculty of Pharmaceutical Sciences, Hokkaido University, Japan

Research Area

Drug regulation of Parkinson’s disease genes and proteins;

Proteomic study on brain neural pathways in morphine-dependent animals;

Protective and therapeutic effects of TCM on experimental hepatic fibrosis

Career

1982-1984 Research assistant Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences

1984-1988 Research assistant Department of Pharmacology, Gansu Institute of Materia Medica, P.R. China

1988-1989 Research staff Oriental Medicine Research Center of the Kitasato Institute, Japan

1995-1997 Post-doctoral research staff Institute of Basic Medical Sciences, Academy of Military Medical Sciences, P.R. China

1997-2002 Associate professor Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center

2002-   Professor Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center

Selected Research Publications

Li S, Pu XP*. Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine -induced mouse model of Parkinson's disease. Biol Pharm Bull. 2011;34 (8):1291-6.

An CN, Jiang H, Wang Q, Yuan RP, Liu JM, Shi WL, Zhang ZY, Pu XP*. Down-regulation of DJ-1 protein in the ejaculated spermatozoa from Chinese asthenozoospermia patients. Fertil Steril. 2011 Jul;96(1):19-23.

Dong M, Si YQ, Sun SY, Pu XP, Yang ZJ, Zhang LR, Zhang LH, Leung FP, Lam CM, Kwong AK, Yue J, Zhou Y, Kriksunov IA, Hao Q, Lee HC Design, synthesis and biological characterization of novel inhibitors of CD38. Org Biomol Chem. 2011 May 7;9(9):3246-57

Wang QQ, Zhao X, Pu XP*. Proteome analysis of the left ventricle in the vitamin D(3) and nicotine-induced rat vascular calcification model. J Proteomics. 2011 Apr 1;74(4):480-9

Gao JW, Yamane T, Maita H, Ishikawa S, Iguchi-Ariga SM, Pu XP*, Ariga H.J DJ-1-Mediated protective effect of protocatechuic aldehyde against oxidative stress in SH-SY5Y cells. Pharmacol Sci. 2011;115 (1):36-44.

 Zhang SP, Du XG, Pu XP*. 3-O-demethylswertipunicoside protects against oxidative toxicity in PC12 cells. Biol Pharm Bull. 2010;33(9):1529-33.

Zhao X, Xiao WZ, Pu XP*, Zhong LJ. Proteome analysis of the sera from Chinese Parkinson's disease patients [J]. Neurosci Lett, 2010, 479(2): 175-179. 

 

Zhang HN, An CN, Zhang HN, Pu XP*. Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo [J]. Neurosci Lett, 2010, 474(2): 99-103.

 

Sun H, Che QM, Zhao X, Pu XP*. Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats [J]. Eur J Pharmacol, 2010, 631(1-3): 53- 60.

 

Yan H, Pu XP*. Expression of the Parkinson's disease-related protein DJ-1 during neural stem cell proliferation[J]. Biol Pharm Bull, 2010, 33(1): 18- 21.

Li Q, Zhao X, Zhong LJ, Yang HY, Wang Q, Pu XP*.Effects of chronic morphine treatment on protein expression in rat dorsal root ganglia.Eur. J. Pharm. 2009, 612(1-3): 21-28.

Yang HY, Pu XP*.Chronic morphine administration induces over-expression of aldolase C with reduction of CREB phosphorylation in the mouse hippocampus. Eur. J. Pharm. 2009, 609(1-3): 51-57.

Qu W, Fan L, Kim YC, Ishikawa S, Iguchi-Ariga SM, Pu XP*, Ariga H. Kaempferol derivatives prevent oxidative Stress–Induced cell death in a DJ-1–Dependent Manner. J. Pharmacol. SCI. 2009, 110: 191-200.

 Li YY, Lu JH, Li Q, Zhao YY, Pu XP*. Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons[J]. Eur J Pharmacol, 2008, 579(1-3): 134- 140.

 Zhao X, Li Q, Zhao L, Pu X P. Proteome analysis of substantia nigra and striatal tissue in the mouse MPTP model of Parkinson’s disease[J]. Proteomics-clin Appl, 2007, 1 (12): 1559 - 1569.

 Geng X, Tian X, Tu P, Pu X. Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson's disease[J]. Eur J Pharmacol, 2007, 564(1-3): 66- 74.